文部科学省科学研究費補助金「新学術領域研究」３次元半導体検出器で切り拓く新たな量子イメージングの展開

D02

D02:Fast and high resolution mass imaging of biomolecules using stigmatic imaging mass spectrometer

We will develop new SOI detector for stigmatic imaging mass spectrometer that can detect arrival position and flight time of incoming ion with high spatial and temporal resolution. By this new SOI detector stigmatic imaging mass spectrometer will be in practical use, and fast high resolution mass imaging of biomolecules can be realized.
This technique is expected to be applied in many fields (biology, pathology, pharmacy and industry) as below;

  • Pathology research and fast diagnosis
  • Observation of biological distribution and disposition of Cs and Sr
  • Pharmacokinetics of new medicine
  • Evaluation of organic electronic device

Member

Kunio Awazu　Group Coordination

Hisanao Hazama　 Development and design of SOI detector

Jun Aoki　Development and design of optics for stigmatic-type imaging mass spectrometor

Michisato Toyoda　 Development of stigmatic-type imaging mass spectrometor

Yosuke Kawai　Development and evaluation SOI detector

Hisanori Matsuoka　Development of control system for SOI detector

Link

Publication

  • 青木順，豊田岐聡, "投影方式飛行時間型イメージング質量分析装置の開発", J. Mass Spectrom. Soc. Jpn., 61 3 (2013) 23-33.
  • 豊田岐聡, 新間秀一, 青木順, 石原盛男, “マルチターン飛行時間型質量分析計”, J. Mass Spectrom. Soc. Jpn. 60, (2012) 87?102.
  • H. Hazama, H. Yoshimura, J. Aoki, H. Nagao, M. Toyoda, K. Masuda, K.Fujii, T. Tashima, Y. Naito, K. Awazu, “Development of a stigmatic mass microscope using laser desorption/ionization and a multi-turn time-of-flight mass spectrometer”, J. Biomed. Opt. 16 (2011) 046007.
  • 間久直, 粟津邦男, “8-3 新規 MS イメーシ?ンク?技術”, 日本臨床フ?ロテオ ーム研究会編「臨床フ?ロテオミクス―ハ?イオマーカー探索から個別化医療へ―」金原出版, (2012) 299?308.
  • J. Aoki, H. Hazama, M. Toyoda, “Novel ion extraction method for imaging mass spectrometry”, J. Mass Spectrom. Soc. Jpn. 59 (2011) 57?61.
  • H. Yoshimura, H. Hazama, J. Aoki, M. Toyoda, Y. Naito, K. Awazu, “Evaluation of a delay-line detector combined with analog-to-digital converters as an ion detection system for stigmatic imaging mass spectrometry”, Jpn. J. Appl. Phys. 50 (2011) 056701.
  • M. Toyoda, "Development of Multi-turn Time-of-Flight Mass Spectrometers and Their Applications", Eur. J. Mass Spectrom., 16 (2010) 397-406.
  • J. Aoki, A. Kubo, M. Ishihara, M. Toyoda, “Simulation of ion trajectories using the surface-charge method on a special purpose computer”, Nucl. Instrum. Methods Phys. Res. A 600 (2009) 466?470.
  • H. Hazama, J. Aoki, H. Nagao, R. Suzuki, T. Tashima, K. Fujii, K. Masuda, K. Awazu, M. Toyoda, *Y. Naito, “Construction of a novel stigmatic MALDI imaging mass spectrometer”, Appl. Surf. Sci. 255 (2008) 1257?1263.
  • H. Hazama, H. Nagao, R. Suzuki, M. Toyoda, K. Masuda, Y. Naito, K. Awazu, “Comparison of mass spectra of peptides in different matrices using matrix-assisted laser desorption/ionization and a multi-turn time-of-flight mass spectrometer, MULTUM-IMG”, Rapid Commun. Mass Spectrom. 22 (2008) 1461?1466.